Studie Heidelberg Corona Kinder

Hanna Renk, Alex Dulovic, watch ORCID ProfileMatthias Becker, Dorit Fabricius, maria Zernickel, daniel Junker, Alina Seidel, Rüdiger Groß, Alexander Hilger, sebastian Bode, Linus Fritsch, Pauline Frieh, Anneke Haddad, Tessa Görne, jonathan Remppis, Tina Ganzemueller, Andrea Dietz, Daniela Huzly, hartmut Hengel, watch ORCID ProfileKlaus Kaier, susanne Weber, Eva-Maria Jacobsen, philip D. Kaiser, Bjoern Traenkle, Ulrich Rothbauer, maximilianer Stich, Burkhard Tönshoff, georg F. Hoffmann, barbara Müller, Carolin Ludwig, bernd Jahrsdörfer, hubert Schrezenmeier, andreas Peter, sebastian Hörber, thomas Iftner, jan Münch, schneidbrett Stamminger, Hans-Jürgen Groß, martin Wolkewitz, Corinna Engel, Marta Rizzi, philipp Henneke, see ORCID ProfileAxel R. Franz, Klaus-Michael Debatin, see ORCID ProfileNicole Schneiderhan-Marra, Ales Janda, watch ORCID ProfileRoland Elling
Hanna Renk
1University children’s Hospital Tübingen, Tübingen, Germany
Alex Dulovic
2NMI Natural and Medical scientific researches Institute at ns University of Tübingen, Reutlingen, Germany
Roles: rer.nat
Matthias Becker
2NMI Natural and Medical sciences Institute at die University von Tübingen, Reutlingen, Germany
Dorit Fabricius
3Department of Pediatrics und Adolescent Medicine, Ulm universität Medical Center, Ulm University, Ulm, Germany
Maria Zernickel
3Department of Pediatrics and Adolescent Medicine, Ulm university Medical Center, Ulm University, Ulm, Germany
Daniel Junker
2NMI Natural und Medical sciences Institute at die University des Tübingen, Reutlingen, Germany
Alina Seidel
4Institute of Molecular Virology, Ulm University, Ulm, Germany
Rüdiger enorm
4Institute des Molecular Virology, Ulm University, Ulm, Germany
Alexander Hilger
5Center zum Pediatrics und Adolescent Medicine, Medical zentral Freiburg, Germany und Faculty von Medicine, University of Freiburg, Freiburg, Germany
Sebastian Bode
3Department des Pediatrics and Adolescent Medicine, Ulm university Medical Center, Ulm University, Ulm, Germany
Linus Fritsch
5Center for Pediatrics und Adolescent Medicine, Medical zentral Freiburg, Germany and Faculty von Medicine, University of Freiburg, Freiburg, Germany
Pauline Frieh
5Center for Pediatrics and Adolescent Medicine, Medical hauptquartier Freiburg, Germany and Faculty des Medicine, University des Freiburg, Freiburg, Germany
Anneke Haddad
5Center for Pediatrics und Adolescent Medicine, Medical center Freiburg, Germany and Faculty of Medicine, University of Freiburg, Freiburg, Germany
Tessa Görne
5Center zum Pediatrics und Adolescent Medicine, Medical center Freiburg, Germany und Faculty von Medicine, University of Freiburg, Freiburg, Germany
Jonathan Remppis
1University children’s Hospital Tübingen, Tübingen, Germany
Tina Ganzemueller
7Institute zum Medical Virology and Epidemiology von Viral Diseases, universität Hospital Tübingen, Tübingen, Germany
Andrea Dietz
6Institute des Virology, Ulm universität Medical Center, Ulm, Germany
Daniela Huzly
8Institute des Virology, university Medical center Freiburg, Germany und Faculty of Medicine, University von Freiburg, Freiburg, Germany
Hartmut Hengel
8Institute von Virology, university Medical hauptquartier Freiburg, Germany und Faculty von Medicine, University of Freiburg, Freiburg, Germany
Klaus Kaier
9Institute des Medical Biometry und Statistics, Faculty of Medicine and Medical Center, University des Freiburg, Freiburg, Germany
Susanne Weber
9Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University von Freiburg, Freiburg, Germany
Eva-Maria Jacobsen
3Department von Pediatrics und Adolescent Medicine, Ulm university Medical Center, Ulm University, Ulm, Germany
Philipp D. Kaiser
2NMI Natural und Medical scientific researches Institute at ns University of Tübingen, Reutlingen, Germany
Bjoern Traenkle
2NMI Natural and Medical scientific researches Institute at the University von Tübingen, Reutlingen, Germany
Ulrich Rothbauer
2NMI Natural und Medical scientific researches Institute at ns University of Tübingen, Reutlingen, Germany
Maximilian Stich
10Department of Pediatrics I, universität Children’s Hospital Heidelberg, Heidelberg, Germany
Burkhard Tönshoff
10Department of Pediatrics I, university Children’s Hospital Heidelberg, Heidelberg, Germany
Georg F. Hoffmann
10Department of Pediatrics I, universität Children’s Hospital Heidelberg, Heidelberg, Germany
Barbara muller
10Department von Pediatrics I, university Children’s Hospital Heidelberg, Heidelberg, Germany
11Department von Infectious Diseases, Virology, Heidelberg University, Heidelberg, Germany
Carolin Ludwig
12Department of Transfusion Medicine, Ulm University, Ulm, Germany
13Institute weil das Clinical Transfusion Medicine und Immunogenetics
14German Red overcome Blood Transfusion Service, Baden-Württemberg, Germany
Bernd Jahrsdörfer
12Department von Transfusion Medicine, Ulm University, Ulm, Germany
13Institute for Clinical Transfusion Medicine and Immunogenetics
14German Red cross Blood Transfusion Service, Baden-Württemberg, Germany
Hubert Schrezenmeier
12Department of Transfusion Medicine, Ulm University, Ulm, Germany
13Institute for Clinical Transfusion Medicine und Immunogenetics
14German Red overcome Blood Transfusion Service, Baden-Württemberg, Germany
Andreas peter
15Institute weil das Clinical Chemistry und Pathobiochemistry, university Hospital Tübingen, Tübingen, Germany
Sebastian Hörber
15Institute zum Clinical Chemistry and Pathobiochemistry, universität Hospital Tübingen, Tübingen, Germany
Thomas Iftner
7Institute zum Medical Virology and Epidemiology von Viral Diseases, university Hospital Tübingen, Tübingen, Germany
Jan Münch
4Institute of Molecular Virology, Ulm University, Ulm, Germany
Thomas Stamminger
6Institute von Virology, Ulm university Medical Center, Ulm, Germany
Hans-Jürgen enorm
16Institute des Clinical Chemistry, Ulm University, Ulm, Germany
Martin Wolkewitz
9Institute von Medical Biometry und Statistics, Faculty von Medicine und Medical Center, University von Freiburg, Freiburg, Germany
Corinna gesichtspunkt
1University children’s Hospital Tübingen, Tübingen, Germany
17Center for Pediatric Clinical Studies, universität Hospital Tübingen, Tübingen, Germany
Marta Rizzi
18Department des Rheumatology and Clinical Immunology, Freiburg university Medical Center, Faculty von Medicine, University des Freiburg, Freiburg, Germany
Philipp Henneke
5Center weil das Pediatrics und Adolescent Medicine, Medical hauptquartier Freiburg, Germany and Faculty von Medicine, University des Freiburg, Freiburg, Germany
19Institute for Immunodeficiency, university Medical center Freiburg, Freiburg, Germany
Axel R. Franz
1University children’s Hospital Tübingen, Tübingen, Germany
17Center for Pediatric Clinical Studies, university Hospital Tübingen, Tübingen, Germany
Klaus-Michael Debatin
3Department of Pediatrics und Adolescent Medicine, Ulm universität Medical Center, Ulm University, Ulm, Germany
Nicole Schneiderhan-Marra
2NMI Natural und Medical scientific researches Institute at the University von Tübingen, Reutlingen, Germany
Ales Janda
3Department des Pediatrics and Adolescent Medicine, Ulm university Medical Center, Ulm University, Ulm, Germany
Roland Elling
5Center zum Pediatrics and Adolescent Medicine, Medical center Freiburg, Germany und Faculty of Medicine, University von Freiburg, Freiburg, Germany
19Institute weil das Immunodeficiency, university Medical center Freiburg, Freiburg, Germany
*

Abstract


Background long-term persistence of antibodies versus SARS-CoV-2, particularly the SARS-CoV-2 Spike Trimer, identify individual protection against infection and potentially viral spread. Ns quality von children’s herbal humoral immune an answer following SARS-CoV-2 infection zu sein yet incompletely understood yet crucial kommen sie guide pediatric SARS-CoV-2 inoculation programs.

Du schaust: Studie heidelberg corona kinder


Methods bei this prospective observational multi-center cohort study, we followed 328 households, consisting of 548 children and 717 adults, with hinweisen least one member with a previous laboratory-confirmed SARS-CoV-2 infection. Ns serological response was assessed punkt 3-4 months and 11-12 month after infection utilizing a bead-based multiplex immunoassay for 23 human coronavirus antigens consisting of SARS-CoV-2 und its Variants des Concern (VOC) and endemic human coronaviruses (HCoVs), und additionally von three commercial SARS-CoV-2 antibody assays.


Results Overall, 33.76% des SARS-CoV-2 exposed children und 57.88% adult were seropositive. Youngsters were five zeit more most likely to oase seroconverted there is no symptoms compared kommen sie adults. Despite the frequently asymptomatic prozess of infection, youngsters had greater specific antibody levels, und their antitoxin persisted longer than in adults (96.22% matches 82.89% ausblüten seropositive 11-12 months post infection). Des note, symptomatic und asymptomatic epidemic induced comparable humoral responses bei all period groups. An symptomatic children, just dysgeusia was found as diagnostic indicator von COVID-19. SARS-CoV-2 infections developed independent of HCoV serostatus. Antibody binding responses to VOCs were similar in children and adults, with lessened binding zum the Beta variant bei both groups.


Conclusions the long-term humoral immune response to SARS-CoV-2 infection an children is robust und may provide long-term protection even after asymptomatic infection.

(Study ID weist German Clinical Trials Register: 00021521)


Competing attention Statement

NSM was a speaker hinweisen Luminex user meetings in the past. Ns Natural and Medical sciences Institute at die University von Tuebingen is involved bei applied research projects as a fee zum services with Luminex. The other authors report no contending interests.

Clinical Trial

German Clinical Trials Register: 00021521

Funding Statement

The covid19 BaWue study was funded by the Ministry von Science, Research and Arts, Baden-Wuerttemberg, Germany (COVID-19 research framework).

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Author Declarations

I confirm all belang ethical guidelines have been followed, and any important IRB and/or values committee approvals oase been obtained.

Yes

The einzelheiten of ns IRB/oversight body that provided approval or exemption zum the research described are given below:

The examine protocol was approved von the independent ethics committees des the MedicalFaculty Heidelberg (S-294/2020), medical Faculty Tuebingen (293/2020BO2), University von Ulm107 (152/20) und University of Freiburg (256/20_201553).

All essential patient/participant consent has been obtained und the proper institutional forms have been archived.

Yes

I recognize that every clinical trials and any other prospective interventional lernen must it is in registered with in ICMJE-approved registry, such as ClinicalTrials.gov. Ich confirm that any such study reported in the manuscript has actually been registered und the trial it is registered ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement an the attempt ID ar explaining why die study was not registered in advance).

Yes

I schutz followed all ideal research reporting guidelines und uploaded the relevant EQUATOR Network research study reporting checklist(s) und other pertinent material as supplementary files, if applicable.

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Yes


Footnotes

Competing Interests NSM was a speaker hinweisen Luminex user meetings in the past. The Natural and Medical scientific researches Institute at the University of Tübingen zu sein involved bei applied research projects as a fee zum services with Luminex. The other authors report no contending interests.